Welcome to Peptide Card of AntiTbPdb

This page displays user query in tabular form.

(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip) details

Primary information
ID	antitb_1846,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis H37Rv
Cell Line	MIC = 6.0 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1847,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Clinical isolate, X004439
Cell Line	MIC = 4.4 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1848,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Clinical isolate, X004244
Cell Line	MIC = 4.7 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1849,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Clinical isolate, X005282
Cell Line	MIC = 4.7 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1850,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Clinical isolate, X005319
Cell Line	MIC = 4.8 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1851,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Clinical isolate, X001354
Cell Line	MIC = 4.7 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1852,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Clinical isolate, X003899
Cell Line	MIC = 4.8 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1853,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to streptomycin (rSM, ATCC 35820)
Cell Line	MIC = 4.7 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1854,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to rifampin (rRMP, ATCC 35838)
Cell Line	MIC = 4.7 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1855,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to kanamycin (rKM, ATCC 35827)
Cell Line	MIC = 4.9 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1856,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to isoniazid (rINH, ATCC 35822)
Cell Line	MIC = 4.7 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1857,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to cycloserine (rCS, ATCC 35826)
Cell Line	MIC = 7.4 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1858,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to moxifloxacin (rMOX)
Cell Line	MIC = 4.0 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1859,
Name	24224794
N-Terminal modification	Hytramycin I
C-Terminal Modification	(METH-Ala)-(D-Pip)-L-( D-Allo-ILE)-Pip-(D-Pip)
Chemical Modification	Free
Linear/Cyclic	Free
Length	METH-ALA= Methylated alanine, D-Pip = piperazic acid moieties, D-Allo-ILE= D form of Allo-isoleucine
Chirality	Cyclic (Intrachain bond between 1-6)
Nature	6
Source	Mix
Species	Natural
Strain	From Streptomyces hygroscopicus strain ECUM 14046
Inhibition Concentration	Mycobacterium tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis resistant to capreomycin (rCAP)
Cell Line	MIC = 4.8 Î¼g/mL
Inhibition Concentration	In vitro
Sequence	2013
Cytotoxicity	None
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	Antibacterial (Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213), Acinetobacter baumannii (ATCC BAA-747), Enterococcus faecalis (ATCC 29212), and Pseudomonas aeruginosa (ATCC 27853)
Tertiary Structure (Technique)	Not Predicted),